231 papers
Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.
On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.
Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.
This study demonstrates that frataxin depletion in dorsal root ganglia sensory neurons causes a reduction in soma size driven by mitochondrial dysfunction-induced AMPK hyperactivation and mTOR suppression, a phenotype that can be rescued by restoring frataxin, inhibiting AMPK, or treating with alpha-lipoic acid.
This study employs yeast two-hybrid screening to map a comprehensive interactome of the yeast SET1C complex, revealing novel connections to RNA biogenesis and nuclear transport while demonstrating that Set1 methylates the AT-hook domain of the chromatin remodeler Snf2, thereby uncovering a new interplay between lysine and arginine methylation.
This study demonstrates that specific combinations of evolutionarily conserved rattlesnake serum metalloproteinase inhibitors (FETUAs) can fully neutralize the lethal effects of diverse viper venoms with significantly greater potency than current commercial antivenoms, offering a promising new therapeutic strategy for snakebite treatment.
This study reveals that the Farnesoid X receptor (FXR) and BET signaling pathways cooperatively protect pancreatic {beta} cells from inflammation-induced dysfunction and loss of identity in diabetes by forming a direct protein-protein interaction, suggesting that combined FXR activation and BET inhibition represents a promising therapeutic strategy to preserve {beta} cell function in both type 1 and type 2 diabetes.
This study reveals that the TREX2 complex functions as a modular system where the scaffold protein PCID2 assembles into distinct, evolutionarily conserved subcomplexes with GANP, LENG8, or SAC3D1 to direct specific RNA processing and export pathways to different cellular compartments.
This study demonstrates that in basal-like triple-negative breast cancer, the dose-dependent regulation of m6A by METTL3 critically controls cellular proliferation and protein synthesis, where partial loss of METTL3 paradoxically enhances translation and growth while strong inhibition suppresses them.
This study demonstrates that dietary lipids derived from a genetically engineered long-lived yeast strain extend the lifespan of *Drosophila* by restoring gut integrity and triggering systemic metabolic remodeling that enhances epithelial function, optimizes brain energy signaling, and strengthens gut-brain communication.
The study identifies the host methyltransferase PCIF1 as a critical factor that catalyzes m6Am methylation on the SARS-CoV-2 RNA cap, a modification essential for efficient viral replication and pathogenicity.
The paper introduces NaP-TRAP, a versatile and accessible reporter-based workflow that utilizes epitope-tagged nascent peptide immunoprecipitation to simultaneously and quantitatively dissect the contributions of cis-regulatory elements to mRNA translation and stability across diverse biological contexts.
This study employs a multi-objective engineering strategy to enhance the thermostability and cofactor flexibility of trimethylamine monooxygenase, successfully identifying variants with improved heat-resistant NADPH activity while revealing the persistent challenge of maintaining NADH function under thermal stress.